I don’t read many comics these days, but I’ve really enjoyed the collections of Y: The Last Man. From Boing Boing, Cory Doctorow’s summary is as good as any:
The plot of Y: The Last Man is a pretty straightforward apocalyptic tale: one day, every man on earth drops dead, blood gushing from their noses and mouths, leaving no one behind but women, and one man, and one male monkey (his pet — a helper monkey he’s been training). The setup rapidly progresses into a gripping, funny, sad and lovely tale of the post-apocalyptic world.
It’s a particularly adult kind of comic, full of literary and pop references and witty dialogue. Via the aforementioned Boing Boing link, I learned that the first issue is available online (PDF). Even if you’ve never been a comic book reader, it’s worth taking five minutes to check out.
DarrenBarefoot.com 
I picked-up all 5 collections this summer and couldn’t put them down! This is, by far, one of the best “graphic novels” I’ve read. Mind you, I don’t read a lot of them, but this instantly one me over and now I’m bursting with excitement for the next collection to come out. Sadly, there’s very little info online, as far as I can tell.